Discovery Technology Intern

Position

Nurix is seeking a scientifically trained Summer Intern to support biochemistry screening and laboratory automation activities within the Discovery Technology group. Nurix is focused on harnessing the ubiquitin proteasome system (UPS) to develop novel therapeutics in oncology, immune‑oncology, and additional disease areas. The intern will contribute to the design, execution, and analysis of high‑throughput biochemical assays and the generation of assay‑ready plates using automated platforms, while driving an independent research project. This position is best suited for a self‑motivated and detail‑oriented undergraduate who thrives in a collaborative, fast‑paced research environment.

Responsibilities

• Familiarize with and utilize laboratory automation platforms to create assay‑ready plates to support internal biochemical and cell‑based screens for collaborators and internal projects.
• Execute experimental protocols for biochemical assays to support targeted protein degrader discovery and optimization.
• Develop and optimize a biochemical assay that can be used for hit validation, including testing assay robustness, dynamic range, and suitability for screening.
• Independently execute basic lab math to support assay setup (e.g., serial dilutions and plate layout calculations) and ensure accurate reagent preparation for high‑throughput screens.
• Analyze experimental data, troubleshoot technical challenges in screening campaigns, and propose innovative solutions to improve assay performance and automation workflows.
• Keep accurate and detailed records of experiments, methodologies, and results in electronic laboratory notebooks and databases, following team and company data integrity standards.
• Present findings at internal meetings and contribute to scientific discussions to drive project advancement within Discovery Technology.

Qualifications

• Current undergraduate or BS in a relevant scientific field (Biochemistry, Pharmacology, Biology, or related discipline) with a strong academic track record.
• Familiarity with MS Excel for data handling, basic analysis, and visualization of plate‑based screening results.
• Foundational experience in a wet‑lab environment (e.g., biochemical or cellular assays, pipetting, buffer and reagent preparation); familiarity with plate‑based assays is a plus.
• Exceptional analytical and problem‑solving skills, with the ability to interpret quantitative assay data and identify trends or issues.
• Impeccable organizational skills and unwavering attention to detail, readily adaptable to the demands of a dynamic research environment and high‑throughput workflows.
• Excellent communication skills, fostering collaboration and teamwork within a diverse and multidisciplinary setting.
• Self‑motivated with the ability to work independently on an assigned project while also contributing to team‑based screening efforts.